The IndieBlocks plugin comes with quite a few settings; the development version even more so. The reason? It has the potential to modify core blocks, and core feeds. And visually hide post titles, add feeds, and so on. And if you’re one of three people who have carefully crafted responses to Micropub’s config queries, it could, potentially, screw that up, too. On a new site or to someone who wanted to try microblogging, “IndieWeb-style,” for the very first time, I’d say, pick a block theme, then enable all of IndieBlocks’ settings (and a separate, for now, Webmention plugin), and fire away. Anything looks off, we’ll “fix it in the mix.” Code snippet here, small tweak there. But with existing sites, no; you’re going to have to see what works for you (and let me know what you’d like to see different).